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Spanish flu research : ウィキペディア英語版
Spanish flu research

Spanish flu research concerns scientific research regarding the causes and characteristics of the "Spanish flu", a variety of influenza that in 1918 was responsible for the worst influenza pandemic in modern history. Many theories about the origins and progress of the Spanish flu persisted in literature, but it was not until 2005, when various samples were recovered from American World War I soldiers and an Inuit woman buried in the Alaskan tundra, that significant research was made possible.
== Origin of virus ==
One theory is that the virus strain originated at Fort Riley, Kansas, by two genetic mechanisms — genetic drift and antigenic shift — in viruses in poultry and swine which the fort bred for local consumption. Though initial data from a recent reconstruction of the virus suggested that it jumped directly from birds to humans, without traveling through swine,〔Sometimes a virus contains both avian adapted genes and human adapted genes. Both the H2N2 and H3N2 pandemic strains contained avian flu virus RNA segments. "While the pandemic human influenza viruses of 1957 (H2N2) and 1968 (H3N2) clearly arose through reassortment between human and avian viruses, the influenza virus causing the 'Spanish Flu' in 1918 appears to be entirely derived from an avian source (Belshe 2005)." (from (Chapter Two : Avian Influenza by Timm C. Harder and Ortrud Werner ), an excellent free on-line Book called ''Influenza Report 2006'' which is a medical textbook that provides a comprehensive overview of epidemic and pandemic influenza.)〕 this has since been cast into doubt. One researcher published in 2004 argued that the disease was found in Haskell County, Kansas as early as January 1918. A similar and even more deadly virus had been seen earlier at British camps in France and at Aldershot.〔''Origins of the 1918 Pandemic: The Case for France''
http://www.npr.org/templates/story/story.php?storyId=5222069〕
Earlier investigative work published in 2000 by a team led by British virologist, John Oxford〔(EU Research Profile on Dr. John Oxford )〕 of St Bartholomew's Hospital and the Royal London Hospital, suggested that a principal British troop staging camp in Étaples, France was at the center of the 1918 flu pandemic or at least a significant precursor virus to it. There had been a mysterious respiratory infection at the military base during the winter of 1915-16.〔Connor, Steve, ("Flu epidemic traced to Great War transit camp" ), The Guardian (UK), Saturday, 8 January 2000〕

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